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PHARMOCOLOGICAL EVALUATION OF METHANOLIC EXTRACT OF DESMOSTACHYA BIPINNATA AGAINST SCOPOLAMINE INDUCED DEMENTIA OF ALZHEIMER’S TYPE IN ALBINO WISTAR RATS

Kondumahanti V N Lakshmi*, M R Kumar, K. ChandraSekhar, S. Manish, K. T. Sunil kumar, K. Prasad, Kumar V S Nemmani

One of the most common cause of dementia is Alzheimer’s disease. The word dementia includes memory loss, difficulties in thinking, problem-solving or language, decrease in social activity. None of the treatments available today for Alzheimer’s disease stops the malfunction and death of neurons in the brain that cause Alzheimer’s symptoms. In traditional use of medicine, many plants are available to treat the symptoms of Alzheimer’s. Desmostachya bipinnata belongs to family of Poacea, is proved for having anti anxiety, anti oxidant, anti inflammatory etc. The present study was designed to evaluate the protective effect of methanolic extract of Desmostachya bipinnata (MEDB) against Scopolamine induced Alzheimer’s type dementia in Albino wistar rats. Alzheimers type dementia was screened by observing behavioural parameters using actophotometer (locomotory activity), morris Water Maze (spatial learning), y maze (exploratory behaviour) and biochemical estimations such as catalase, glutathione, acetyl cholinesterase, malondialdehyde. The MEDB shown that the decrease in the symptoms of Alzheimer’s type dementia by ameliorating locomotory activity, spatial learning, exploratory behaviour and increased antioxidant enzyme levels in the brain Keywords: Desmostachya bipinnata, Actophotometer, Morris water maze, Y maze, Catalase, Acetyl cholinesterase, Glutathione, Malondialdehyde.

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