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RISK FACTORS ASSOCIATED WITH EARLY-ONSET COLORECTAL CANCER

Dr Zara Nasir,Dr Zaib Nasir,Dr Adeel Ahmed

Introduction: early-onset colorectal cancer appears to display an opposite trend with an overall prevalence in United States and European Union ranging from 3.0% and 8.6%. Colorectal cancer has a substantial proportion of familial cases. Colorectal cancer is the third most common cancer diagnosed worldwide. Although epidemiology data show a marked variability around the world, its overall incidence rate shows a slow but steady decrease, mainly in developed countries. Aim: Our aim was to compare the early- and late-onset groups to identify differences in sociodemographic factors and clinical risk factors, as well as tumor characteristics. Age-related medical conditions such as hypertension, hyperlipidemia, coronary artery disease, stroke, and diabetes were only compared between early-onset cases and controls. Methods: We conducted a retrospective chart review of patients who were seen at Kot Khawaja Teaching Hospital in Lahore. We identified all patients aged 18 and older with a diagnosis of CRC who received care at our institution. Discussion: the majority of early-onset CRC cases in our single-centre study were sporadic. Patients with early-onset CRC were more likely to be male and have a family history of CRC or personal history of IBD.

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