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A REVIEW ON MEDICATED CHEWING GUM

JUNO S * , SUBASH CHANDRAN M.P, PRASOBH G.R, SUBODH S SATHEESH, POOJA NAIR K R, ANU A L, SARANYA S

Chewing gums are mobile drug delivery systems. Unlike chewable tablets medicated gums are not supposed to be swallowed and may be removed from the site of application without resort to invasive. Medicated chewing gum is solid, single dose preparation with a base consisting mainly of gums that are intended to be chewed but not swallowed. Several ingredients are now incorporated in medicated chewing gum, e.g. Fluoride for prophylaxis of dental caries, chlorhexidine as local disinfectant, nicotine for smoking cessation, aspirin as an analgesic, and caffeine as a stay alert preparation. In addition, a large number of chewing gum intended for prevention of caries, xerostomia alleviation, and vitamin/ mineral supplementation are currently available. As for as patient convenience is concerned it is discrete and easy administration without water promotes higher compliance. Since it can be taken anywhere, a chewing gum formulation is an excellent choice for acute medication. The advantages for children and for patients who find swallowing tablets difficult are obvious. Today improved technology and extended know how have made it possible to develop and manufacture medicated chewing gum with predefined properties. The present review article is nicely discussed advantages, disadvantages, formulation, manufacturing process, limitation of manufacturing process, factors affecting release of active substance, quality control tests for chewing gum. Keywords: Chewing gum, non adhesive, drug delivery, sustain release

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