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DETERMINATION OF THE TERMS OF DIFFUSION OF CHLORHEXIDINE ACETATE FROM THE FILLING MATERIAL "RESTAVRIN" IN THE PHOSPHATE-SALT BUFFER

Razumova Svetlana, Volina Elena, Koroleva Irina, Bragunova Ruzana, Kozlova Yuliya., Tigranyan Khachik,

Objective: The problem of secondary caries after restoration is actual in our days. Сhlorhexidine is one of the most common antiseptics used in dentistry with proven bactericidal efficacy. The aim of this work was to predict long-term antibacterial activity, determine the presence and rate of diffusion of CHX from the “Restavrin” filling material into phosphate-buffered saline.Materials and methods: Samples of the composite material "Restavrin" were made with a concentration of 0.5% and 5.0% CHX. 4 ml of phosphate-buffered saline (PBS) with pH = 7.4 was added to polystyrene tubes. 10 tubes with PBS were prepared, in which were placed 4 disks of “Restavrin” filling material with 0.5% CHX, and 10 tubes with PBS were placed in 4 disks of Restavrin filling material with 5.0% CHX. All tubes were incubated for 70 days at 37 ° C.Results: The degree of sensitivity of microorganisms to samples of “Restavrin” filling material with 0.5% and 5.0% CHX when exposed to the PBS for 70 days is slightly reduced. No statistically significant differences were obtained when comparing the results of a study of the sensitivity of S. mutans and L. salivarius to samples of “Restavrin” filling material with 0.5% and 5.0% CHX and the results of a study of the timing of CHX diffusion in PBS.Conclusion: The prolonged presence of “Restavrin” filling material with AMA in the carious cavities, due to the weak solubility of CHX and its low diffusion into the oral fluid, has only a local effect and does not affect the composition of the oral biocenosis Keywords: chlorhexidine, antiseptics, bactericidal efficacy, composite material, antimicrobial additives

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