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ANALYSIS OF USE OF COLLOID NANOPARTICLES FOR MYOCARDIAL DELIVERY IN ULTRASOUND-TARGETED MICRO BUBBLE DESTRUCTION

Ussama Razzaq Cheema, Uzma Mubarik, Amir Shabeer

Introduction: Ultra sound (US) targeted micro bubble destruction (UTMD) is a encouraging method for delivering genetic material to the heart. The aim of this study was to test whether colloid nanoparticles can be delivered to the rat myocardium using UTMD and to determine whether tissue damage and contractile dysfunction occurs in hearts exposed to UTMD in vivo conditions. Material and Methods: This descriptive study was conducted in Rural Health Centre Mubarakpur, District Bahawalpur during January 2019 to July 2019. Hearts from anaesthetized rats were exposed to per fluorocarbon-enhanced sonicated dextrose albumin (PESDA) (at two different micro bubble concentrations) and US at peak pressures of 0.6, 1.2, or 1.8 MPa for 1, 3, or 9 min. During US, pairs of 30 and 100 nm fluorescent nano spheres were infused intravenously. Rats exposed to PESDA alone or US alone showed no functional abnormalities, no capillary ruptures, and no nanosphere delivery. Results: The data are expressed with the mean values and mean+1 standard error means (SEM). The differences in nano particulate delivery, premature ventricular contraction (PVCs), and vascular rupture between groups was assessed using a two way analysis of variance (ANOVA), examining the effect of two fixed factors. Conclusion: UTMD allows for colloid nano particles to be delivered to the rat myocardium through micro vessel rupture sites. The efficiency of ultra sound medicines supported local delivery depends on the different things which are applied peak pressure, the time duration of ultra sound exposure, and contrast concentration.

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