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IINTERLEUKIN-6 LEVELS IN CASES OF ANGINA PECTORIS

Hafiza Maryam Mushtaq, Rehman Saeed, Zaira Shafiq

Chest pain is well reported in emergency settings and angina pectoris reveals sever underlying cardiovascular disease. The search for various inflammatory markers including interleukin 6 (IL-6) to label it is under investigation. Objective: To determine the frequency of raised Interleukin-6 levels in patients with angina pectoris. Methods: This cross sectional study was conducted at Nawaz Shareef Teaching hospital, Lahore, CMH Lahore and DHQ, DG Khan, between the periods of January 2019 to June 2019; where 100 cases of angina pectoris with normal ECG and cardiac enzymes were included and their detailed sociodemographic and clinical history was taken. Three ml of venous blood was collected in a sterilized disposable syringe and assessed for IL-6 level. The values more than 5 ng/ml were considered as raised. Results: In this study there were total 100 cases out of which 66 (66%) were males and 34 (34%) females. The mean age was 54.19±6.72 years. There were 70 (70%) cases that had age more than 50 years. There were 18 (18%) cases with DM, 28 (28%) had HTN and 42 (42%) had smoking history positive. Raised IL-6 was seen in 72 (72%) of cases. Raised IL-6 were almost equal in both genders (p= 0.89) while it affected more with age group of more than 50 years comprising 80% of its respective group with p= 0.07. IL-6 levels were significantly higher in cases with DM and HTN with p values of 0.04 and 0.02 respectively while this difference was not significant in smokers and non smokers. Conclusion: Angina pectoris is a first step towards to ischemic cardiac diseases. Raised IL-6 levels are almost seen in every 3 out of 4 (72%) cases. These levels are significantly raised in cases with DM and HTN. Key words: Angina Pectoris, DM, HTN, IL-6.

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