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SEVERE THROMBOCYTOPENIA IN PATIENTS WITH SECONDARY DENGUE HEMORRHAGIC FEVER IN PAKISTAN

Dr Salma Kadir, Dr Zohaib Feroze Memon, Dr Musarat Jehan Baloch, Dr Naila Jabeen Baloch, Zoobia Zaheerudin

Objective: To evaluate the frequency of severe thrombocytopenia in patients with dengue hemorrhagic fever in a tertiary care hospital in Pakistan Methodology: A cross sectional study was conducted at Liaquat National Hospital, Hyderabad, Pakistan between September 2018 and January 2019. All patients presenting with consistent fever and tested positive for dengue fever were included in the study. Those with obvious signs and symptoms of other diseases and were negative for dengue IgM and/or IgG were excluded from the study. Demographic and clinical characteristics; age, gender, marital status, job status, number of children, laboratory reports, and serological data were recorded. Data was further stratified into two groups, Dengue Fever and Dengue Hemorrhagic Fever. SPSS v 24 was used to analyze data. A p-value of <0.05 was considered statistically significant. Results: A total of 170 patients were included in the study. The mean age of patients was 29.5 + 12.41 years. Out of the 170 patients, 27 (9.8%) were diagnosed with secondary dengue fever. In the present study, it was found that in patients with primary dengue fever, 80 (55.9%) had mild, 44 (31.1%) had moderate, and 19 (13.0%) had severe thrombocytopenia, whereas; in patients with secondary dengue fever 7 (26.9%) had mild, 14 (53.8%) had moderate, and 5 (19.2%) had severe thrombocytopenia (p=0.0001). Conclusion: The present study indicates that severe thrombocytopenia is a frequent clinical manifestation in patients with dengue hemorrhagic fever. Keywords: dengue fever, dengue hemorrhagic shock, platelets, thrombocytopenia

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