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MULTI LAYERED TABLETS: INNOVATIVE TRENDS IN ORAL DELIVERY

SUBODH S SATHEESH*, Dr. PRASOBH G R, Dr. SHAIJU S DHARAN, Dr. SUBASH CHANDRAN, JUNO S, ANU A L

Multilayer tablet is a new era for successful development of controlled release formulation along with various features to provide successful drug delivery. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bilayer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation, and to enable the development of different drug release profiles (immediate release with extended release). Despite their advantages, due to the use of different materials and complex geometric boundaries between the adjacent layers, the mechanical structures of this drug delivery system have become quite intricate, requiring complicated tablet architectures as well as patient-friendly. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. In the case of bilayered tablets drug release can be rendered almost unidirectional if the drug can be incorporated in the upper nonadhesive layer its delivery occurs into the whole oral cavity. This review explains fundamentals of bilayer tablet system along with its fabrication techniques, different approaches, characterization, and challenges in Bilayer tablet manufacturing and recent developments in the field of bilayer technology. Keywords: Multilayer tablets, Active Pharamaceutical Ingredient, Immediate Release, Drug release, Drug Delivery.

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