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A CROSS-SECTIONAL STUDY TO FIND OUT THE RELATIONSHIP OF HEPATITIS C VIRUS INFECTED HEPATOCELLULAR CARCINOMA WITH RAISED SERUM Α-FETOPROTEIN LEVELS

Dr Majid Khushi, Dr Khansa Tariq, Dr Shahid Zada

Objectives: To determine the frequency of deaths in hepatitis C virus infected hepatocellular carcinoma patients, and its relationship with raised serum alpha-fetoprotein levels. Methods: The cross-sectional study was conducted at Services hospital, Lahore from June, 2018 to May, 2019 and comprised all patients diagnosed with hepatitis C virus and hepatocellular carcinoma over 30 years of age. Blood sample was drawn for the measurement of serum Alfa fetoprotein levels. Data was analyzed using SPSS 20. Results: The mean age of the 165 patients was55.49±11.67 years. The mean tumor size was 5.63 ± 2.14cm. Of the total, 31(18.8%) patients had tumor size <3cm, 65(39.4%) 3-5cm and 69(41.8%) >5cm. The mean serum Alfa fetoprotein level was 7641.0±3665.32 IU/ml. Overall mortality rate was 70(41.9%). Tumor size >5cm was significantly associated with mortality (p=0.016). Conclusion: Serum Alfa fetoprotein levels were a useful tool for the detection of hepatocellular carcinoma in hepatitis C virus patients. Keywords: Hepatitis C virus, Hepatocellular carcinoma, Alpha fetoprotein levels.

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