::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

News Updates Latest Volumes: COSMOS IMPACT FACTOR (2018)- 4.153, GLOBAL IMPACT FACTOR(2014) - 0.384, (2015) - 0.437, Indo American Journal of Pharmaceutical Sciences,

ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

TITLE:

EFFICACY OF MAGNESIUM SULPHATE TO CONTROL MUSCLE SPASM IN CHILDREN WITH MODERATE TO SEVERE TETANUS

AUTHORS:

Dr Hamza Khalid, Dr Rakhshanda Raees, Dr Abida Rehman, Dr Fiza Anwer

ABSTRACT:

Introduction: Tetanus is an acute neurological but vaccine-preventable disease caused by Clostridium tetani that causes significant morbidity and mortality among children in developing countries. Objectives: The basic purpose of the study is to analyse the efficacy of magnesium sulphate to control muscle spasm in children with moderate to severe tetanus. Methodology of the study: This cross sectional study was conducted in Health Department Punjab during June 2019 to December 2019. The data was collected from 200 children of both genders. The diagnosis of tetanus was clinical, based on medical history and examination, determining the presence of at least three of the following clinical findings: severe trismus, refusal to feed, generalised muscle rigidity, opisthotonus or spontaneous tetanic spasms. Results: The data was collected from 200 patients. There were 67(63.5%) males and 33 (36.5%) females. Overall, the mean age was 6.56+3.15 years, and the commonest age group at presentation was 6-10 years with 38(51.4%) cases. 50(67%) were unvaccinated, none (0%) had received booster dose and post-trauma immune prophyl axis. The case fatality was therefore 61.8%, and did not vary significantly over the 14 years (P = 0.536). Conclusion: It is concluded that this study has documented high case fatality rates in Pediatric tetanus in the study area. MgSO4 alone is effective in mild-to-moderate tetanus but not when it is severe.