::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

PREVALENCE OF LATENT TUBERCULOSIS INFECTION IN THE PATIENTS SUFFERING FROM HIV INFECTION

AUTHORS:

Dr Muhammad Asif Shahzad, Dr Wafa Zahid Soomro, Dr Kainat Haq

ABSTRACT:

Objective: The aim of this research work was to find out the prevalence of LTBI (Latent Tuberculosis Infection) and to provide the comparison of the results of Tuberculin Skin Test (TST) to Anti TB-IgM Antibodies (ATIA) for the identification of the LTBI in the patients suffering from HIV infection. Methodology: In this research work, total 62 samples having HIV infection underwent Tuberculin Skin Test in Department of Infectious Diseases of Mayo Hospital Lahore. All these patients underwent Tuberculin Skin Test with the utilization of 5.0 TU of purified protein derivative and we also measured ATIA. We used the SPSS V.21 for statistical analysis of the collected information. Results: 62 patients, 54.80% (n: 34) patients were present with Tuberculin Skin Test positive results, whereas 9.70% (n: 6) patients got positive results for ATIA. There was 45.20% overall concordance between Anti TB-IgM Antibodies & Tuberculin Skin Test (Kappa= 0.370, P= 0.320). In the patients having positive test findings by either ATIA or Tuberculin Skin Test, only 4.80% patients got positive findings by both of the tests. Discordant findings were present in 54.80% patients. Positive findings for both type of tests in patients classified in 2 groups (below or above 200.0 CD4-cell/mm3) were present with no important disparity (P>0.050). Conclusion: Prevalence of Latent Tuberculosis Infection among patients with HIV infection in studied region is much high as compared to other regions of world. TST is very effective test for diagnosis of Latent Tuberculosis Infection and it has preference over ATIA. Concordance between both results was very low. Keywords: HIV Infection, Latent Tuberculosis Infection, Disparity, Tuberculin Skin Test.