::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

INSILICO AND INVTRO ANTI CANCER EVALUATION OF CINCHONINE ALKALOID: AS APOPTOSIS INDUCING AGENTS IN HUMAN HT- 29 CELL LINE INTRODUCTION

AUTHORS:

Mallavarapu CletuS*, G. Subba Rao, B. Ramakrushna, MD. Sameer, M. Mansur Basha, M. Arun Kumar, G. Mercy Parimala, M. Isaac Sunil KUMAR, Y. Sudheer, M. Salomanu

ABSTRACT:

To evaluate the In silico and In vitro of anti-cancer potential of Cinchonine alkaloid: as apoptosis inducing agents on HT-29 Cell line. Selection of alkoloid by molecular docking. MTT Assay on Cinchonine on HT-29 cellline. Apoptosis study by flowcytometry. In silico drug likeness and toxicity prediction of Cinchonine reveals that they are safe (no Mutagenicity, Tumorigenicity, Irritating effect, Reproductive effect). Cinchonine on in vitro method demonstrate anticancer activity on HT-29 cell line and induce the apoptosis. Further studies of Cinchonine were required to explore the mechanism of apoptosis in HT-29 cell line. cinchonine may be a promising lead molecule for the anticancer drug development on HT-29 cell line. Keywords: In silico and In vitro of anti-cancer, Cinchonine alkaloid, molecular docking, HT-29 Cell line.