Dr Misbah Hameed,Dr Itfa Maheen,Dr Ushna Nayyab
Background: Letrozole has higher ovulation rate as compared to Clomiphene citrate which has different measures of the endometrial lining as well as pregnancy outcomes. Objective: to study the effects of usage of Clomiphene citrate versus those of Letrozole in ovulation induction in Polycystic Ovarian Syndrome. Materials and methods: A prospective Randomized trial was carried out in a tertiary level infertility center considering of about 100 infertile patients. 50 patients were given 5 mg Letrozole and 50 were given with 100 mg clomiphene citrate daily from the starting day of menstruation from day 2 to day 6 human gonadotrophin injection was given and timely intercourse was to be done 24 to 36 hours. Results: the ovulation rate was high in Letrozole given patients 75% as compared to Clomiphene citrate which was about 65% Conclusion: Letrozole is more effective as compared to Clomiphene citrate. The side effects of the latter would be quiet harmful. Keywords: Polycystic Ovarian Syndrome, Clomiphene citrate, Letrozole, estrogen, ovulation.