::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

STUDY TO DETERMINE THE SKIN DISORDERS AMONG PATIENTS ON ORAL CORTICOSTEROIDS

AUTHORS:

Dr Talha Shamshad, Rashid Nawaz, Dr Usama Bin Abid

ABSTRACT:

Introduction: Corticosteroids revolutionized the treatment of many skin diseases in the fifth and sixth decades of the last century. They have anti-inflammatory, vasoconstrictive, anti-proliferative and immunosuppressive effects. Aim: The aim of the study was to determine the frequency of skin lesions in patients taking oral steroids and to understand the pattern of these changes in our population. Material and methods: The study was conducted in dermatology department of Allied Hospital Faisalabad for six months duration from 1st April 2020 to 30th September 2020. 204 patients who met the inclusion criteria completed the study. All patients were taking 60-80 mg of oral steroids for a minimum of 2 weeks. The results were recorded on a previously prepared pro forma. All relevant investigations were also carried out. The results were then compiled and tabulated. Results: Multiple skin infections was the most common adverse reaction observed in 45 patients (22%, p> 0.10). The face of the moon was visible in 39 patients (19%, p0.08). Atrophic changes occurred in 45 patients (22.5%, p> 0.47). Other symptoms observed in our patients were acne-like eruptions in 18 patients (8.7%, p0.013). Conclusion: Oral steroid therapy is associated with significant cutaneous side effects that are dose and duration dependent. Bacterial infections remain the most common side effect. Key words: oral steroids, infections, atrophy, moon face, buffalo hump.