::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

GASTRIC AND ESOPHAGEAL EMPTYING IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

AUTHORS:

Dr Rao Farhan Saleem, Dr Own Abbas, Dr Nimra Anwar.

ABSTRACT:

A very common complication in diabetes mellitus is abnormal gastrointestinal mobility. In diabetic patients gastric and oesophaageal symptoms are very remarkable due to gastrointestinal symptoms and it leads to delayed gastric emptying which consequently increases the level of blood glucose. A study conducted on type 1 diabetic patients has demonstrated that there was 42% delay in solid bolus in oesophegal emptying whereas there was 56% delayed in gastric emptying solid or liquid component. Studies have reported that there is more significant gastrointestinal motility disorder in type 2 diabetes mellitus as compare to type 1. A test which is known as 9 emptying was performed. First of all 5ml of water was taken as a lubricant after that the participants was allowed to take the solid meal and was command to swallow the after every 15s. Meanwhile the cricoid movement was analyzed in the monitor to verify that bolus had entered esophagus. Until the bolus reached stomach this test was continued in monitoring. Analysis was performed by computer-drawn regions of interest corresponding to the oesophagus and the stomach. The time for 95% of the radioactivity to enter the stomach was calculated. Although plasma glucose and glycosylated haemoglobin concentrations correlated closely in current, there was no significant relationship between gastric emptying and glycosylated haemoglobin.