Hafiz Muhammad Tousif Afzal, Hassan Bin Aziz, Moaz Ahmad
Background: Type-1 DM (Diabetes Mellitus) is an autoimmune disease and this disease has association with many autoimmune abnormalities, availability of the thyroid antibodies could have negatively influenced on the control of diabetes. The aim of this study is to investigate the thyroid autoimmunity in the pediatric and adolescents’ patients suffering from Type-1 DM and the effect of the presence of abnormalities of thyroid autoimmunity on the control of diabetes in pediatric patients of Type-1 DM in Pakistan. Methodology: This research work was carried out at Mayo Hospital Lahore. The duration of this study was from January 2019 to July 2020. We analyzed the data of 120 patients suffering from Type-1 DM, having age from 1 to 16 years who got treatment and they were coming for follow-up in our diabetic clinic. Tests of thyroid functions, anti-TG (Antibodies to thyroglobulin) and anti-TPO (Thyroperoxidase) were calculated, recorded and associated with the control of diabetes according to the level of HbA1c (Glycated Hemoglobin). Results: In total 120 patients, positive anti-TG (Antibodies to Thyroglobulin) were higher in ≤ three years group of DM and negative anti-TG was lower in > three years of group of DM with results which were statistically significant (P=0.0430).Concerning the thyroid antibodies (AB) distribution in accordance to the HbA1c group, we found a progressive positive anti-TPO titer with the glycemic status, there was lowest positive anti-TPO for good glycemic control and the group with poor glycemic control had the greatest positive anti-TPO titer and all these findings were significant statistically (P=0.0480). Conclusions: There may be association of the thyroid autoimmunity with poor control of diabetes and elevated level of TSH, showing the sub-clinical hypothyroidism that may have influence on the diabetic control. KEYWORDS: Autoimmunity, Type-1 DM, Glycemic, Hypothyroidism, Hemoglobin.