::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

DIAGNOSTIC VALUE OF THE AST/ALT RATIO AS AN INDICATOR OF CIRRHOSIS IN CHRONIC LIVER DISEASES

AUTHORS:

Dr Zunaira Kayani, Dr Tehrim Nisar, Dr Ujala Malik

ABSTRACT:

Introduction: Liver is a complex organ with interdependent metabolic, excretory and defence functions. Objectives: The main objective of the study is to analyze the diagnostic value of the AST/ALT ratio as an indicator of cirrhosis in chronic liver diseases. Methodology of the study: This cross-sectional study was conducted at Rawalpindi Medical University during October 2019 to February 2020. The data was collected through non-probability sampling technique. The data was collected from 100 liver cirrhosis patients. The age range for this study was 20 to 60 years. Blood sample was collected for the serum analysis of liver enzymes. Results: The data was collected from 100 patients of both genders. The mean age of the patients were 45.67±3.56 years. The levels of ALT in patients was 258.2±91.73, 79.66±28.63, and 50.73± 8.4 respectively as compared to normal control (11±3.42). Aspartate aminotransferase levels were significantly raised in viral hepatitis, alcoholic liver disease and cirrhosis patients. Conclusion: It is concluded that the level of all liver enzymes become increases in cirrhosis condition. Liver associated enzymes tests are used to detect, specifically diagnose, and estimate the severity of hepatic disease.