::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

News Updates Latest Volumes: COSMOS IMPACT FACTOR (2018)- 4.153, GLOBAL IMPACT FACTOR(2014) - 0.384, (2015) - 0.437, Indo American Journal of Pharmaceutical Sciences,

ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

TITLE:

HEPATITIS B VIRUS INFECTION IN A PEDIATRIC HEMATOLOGY AND ONCOLOGY UNIT IN PAKISTAN EPIDEMIOLOGICAL INVESTIGATION AND MEASURES FOR PREVENT FURTHER TRANSMISSION

AUTHORS:

Dr Khalid Mehmood, Dr Sidrah Naz, Dr Mazher Hussain Shah

ABSTRACT:

Aim: Hepatitis B (HBV) disease has been portrayed everywhere and continues to occur worldwide. Subsequent nosocomial flare-ups have been linked to risky infusion repetitions, the use of multi-compartment vials, and the failure of staff to follow standard safety measures. This report describes a nosocomial outbreak that occurred in a pediatric hematology and oncology unit of a large school medical clinic, the epidemiological review of the outbreak, and updated preventive estimates to further limit transmission in the clinic. Methods: 53 cases of HBV contamination have been confirmed in 408 patients judged between March 2019 and February 2020 at Services Hospital, Lahore. Episode review, including contact follow-up and HBV screening, was initially performed on all patients seen by the unit for a period similar to that of the first three cases. Routine screening for all patients on the unit began in March 2019, when it was understood that several patients may have been discovered. Results: 53 cases of HBV contamination have been confirmed in 408 patients judged between March 2019 and February 2020 at Services Hospital, Lahore. Phylogenetic examination of the preC/C quality nucleotide clusters of HBV revealed that all tested outbreak strains clustered together. In general, (68%) of patients were HBeAg-positive. The reason for transmission could not be established. Preventive measures guided three treatment proposals. HBV screening and immunization conventions were implemented in the unit. Conclusion: The high number of HBeAg-positive patients, as well as suspected slippages in contamination avoidance and control measures, are recognized as having played a significant role in transmission. The measures implemented to prevent transmission in medical clinics have been effective. The HBV screening and vaccination programs underway in pediatric hematology and oncology units should receive quality care. Keywords: Hepatitis B Virus Infection, Pediatric, Epidemiological Investigation.