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OXIDATIVE MODIFICATIONS IN SICKLE CELL ILLNESS: PROBABLE CONTRIBUTION IN AILMENT PATHOGENESIS

Dr Faiza Khalid, Dr. Lojain Maqsood, Dr Sumbul Zahra

Sickle cell disease (SCD) remains to be primary molecular illness in our current research. Though physical variation similarly dysfunction of current sickle hemoglobin remains fine known, many factors modifying the medical symbols in addition signs of illness remain underneath study. The current research was conducted at Services Institute of Medical Sciences, Lahore, Pakistan from April 2018 to March 2019. As well with the irregular electrophoretic flexibility besides solubility, HbS remains unbalanced. The autooxidation degree of irregular HbS was described to remain practically 2 times of standard. Here remain 2 extra workings of oxidative injury in Sickle cell disease: Permitted radical persuaded oxidative injury throughout vaso-occlusion persuaded ischemia-reperfusion damage also reduced antioxidant dimensions in erythrocyte also in movement. Researcher’s will discourse possessions of oxidative variations in erythrocyte in addition in plasma of Sickle cell disease cases in the current research. Keywords: Oxidative pressure; SCD; Iron; Protein oxidation; Carbonyl set; Sulfhydryl set; Low-thickness lipoprotein; High-thickness lipoprotein.

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