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ANALYSIS OF EXCESSIVE USE OF PPIS ASSOCIATED WITH THROMBOCYTOPENIA IN PAKISTAN

Qasim Hussain, Muhammad Saqib, Muhammad Farooq Afaq

Introduction: Proton pump inhibitors (PPIs) are the most commonly used class of drugs for the treatment of gastric acid-related disorders. Aims and objectives: The main objective of the study is to analyse the excessive use of PPIs associated with thrombocytopenia in general population. Material and methods: This cross sectional study was conducted in Bahawalpur Victoria Hospital during 2018 to 2019. The data was collected from 50 patients who were used PPIs. Then we collect the blood sample of these 50 patients to count the thrombocytes in blood. All the patient had a past medical history of a duodenal ulcer. The patient had taken non-steroidal anti-inflammatory drugs. Results: The data was collected from 50 patients. We found a trend of slight decrease in white blood cells and neutrophils in all the patients. On review of medications, since there were no other drugs (except for one prophylactic dose of heparin) that could be attributed to thrombocytopenia, it was recommended to hold the PPI. The PPI was then stopped, and platelet count recovered to 99 × 103/mm3 within two days. Upper endoscope performed at that time revealed nonspecific gastritis. Biopsies were found to be negative for Helicobacter pylori infection. Conclusion: It is concluded that PPIs should be among the differential diagnosis of thrombocytopenia.

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