Dr. Hamza Ali, Dr. Ali Faheem, Dr. Javeria Bushra Touqir
Background: We considered the impact of spoken antihypertensive preliminary treatment on the acceptance portion of hypodermic barbiturate and its impact on before surgical treatment haemo-dynamics. Appropriate premedication is significant all in all anesthesia cases to lessen uneasiness, to create sedation absence of pain, amnesia and to keep up hemo-dynamical security during peri usable period. Methods: Portion of barbiturate needed and before surgical treatment comparison of somaesthesia, decompress circulatory strain and pulse in the two gatherings surveyed. All patients were separated into two gatherings. Sixty ASA score 1 and score II sufferers were isolated in to both faction, Group 1(study gathering) pre cured with oral clonidine 4mcg/kg/body wt.,Group II(control gathering) (no examination medication managed). Statistical analysis: Huge level for dismissing invalid speculation was taken p < 0.05. The information was broke down utilizing two followed tests for contrasts between methods for both models (Z test) and in required circumstance utilizing x2 test. Results: There was an exceptionally huge ascent of systolic blood pressure, diastolic circulatory strain and pulse in charge group (group II) contrasted with gathering I(study gathering). The acceptance operator thiopentone sodium portion necessity is altogether diminished in gathering I (study gathering) clonidine pre medicated patient contrasted with control group (Group II) (p esteem <0.0001). Conclusion: It is finished up from the aftereffects of this investigation that Pre drug with clonidine 4mcg/kg body weight an hour and a half before enlistment with thiopentone diminishes the necessity of thiopentone and furthermore weakens the pressor reaction during delicate and smooth direct laryngoscopy and intubation. Keywords: Clonidine, thiopentone sodium, perioperative hemodynamic.