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TITLE:

A COMPARATIVE RESEARCH TO CORRELATE LEVEL OF THALASSEMIA MARKERS AMONG THALASSEMIA CONTROLS, MAJOR AND INTERMEDIA PATIENTS

AUTHORS:

Dr. Hamad Khalif Adnan Naseer, Dr. Momina Bukhari, Dr Muhammad Umer Khalid

ABSTRACT:

Background: Thalassemia remains to be the procured hemoglobinopathy due to the quantitative defect in globin chain mix. Clinically, thalassemia is divided into thalassemia genuine (TM), thalassemia intermedia (TI) and thalassemia minor. Various studies have proven the augmentation event of thromboembolic events, especially in TI. Therefore, the plasma levels of the thrombin-antithrombin complex (TAT) and the prothrombin fragment1+2 (F1+2) should be extended in these individuals. Objective: The objective of the current study was to associate levels of those markers in thalassemia main, thalassemia intermedia in addition standard fit measured patients. Methodology: One relative cross-sectional study was performed at Thalassemia Prevention Center of Mayo Hospital and Lahore General Hospital. The hard and fast 24 common strong masses, 24 Thalassemia Major (TM) and 24 Thalassemia Intermedia patients shared in the assessment. Plasma levels of TAT complex and F1+2 were measured in all blood tests. The data were recorded and researched. Results: The average duration of control remained 13.6 ± 8.1 years, and in cases with heavy and thalassemic intermedia it was 13.94 ± 8.69 years and 13.64 ± 8.5 years exclusively. The mean age was demonstrably the same at all three social events, p-regard > 0.05. 11 (45.83%) individuals and 13 (54.17%) women were fused under controls also TI bundles, including real thalassemia, 14 (58.33%) individuals and 10 (41.67%) women. The mean thrombin-antithrombin complex among controls was 3.4±0.8, among cases with thalassemia major 5.0±1.9 and thalassemia intermedia 6.4±2.7 with a quantifiably enormous mean differentiation between study meetings (p-value=0.001). The mean prothrombin F1+2among control was 0.94±.19, among cases with thalassemia major 1.10±1.7 and thalassemia intermedia 1.36±0.27 with a really significant mean difference between social occasions of the examination (p-value=0.001), with the main estimates of those markers in TI. Conclusion: The hypercoagulable condition stayed established in thalassemia major and Intermedia when it looked different in terms of control of social affairs, as evidenced by increasingly increased measurements of TAT and F1+2 in both thalassemia meetings. While the mean thrombin-antithrombin complex (ng/ml) and the mean prothrombin F1+2 (nmol/L) value in the TI were most important with p-value < 0.05. Keywords: Thalassemia main, thalassemia Intermedia, plasma levels, thrombin-antithrombin composite, Prothrombin fragment1+2 (F1+2)

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