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ANALYSIS OF VITAMIN D AS A NEW BIOMARKER OF NEPHROPATHY IN DIABETIC PATIENTS OF PAKISTAN

Muhammad Abubakar, Rifat Noor, Naeem Ahmad

Introduction: Diabetes mellitus (DM) belongs to a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Objectives: The main objective of our study is to find the role of vitamin-D as a biomarker in investigation of nephropathy in diabetic patients in Pakistan. Methodology of the study: This cross sectional study was conducted in District Headquarter Hospital Lodhran during January 2019 to July 2019. For this purpose we collected the data of 100 patients that were selected for further analysis. Those who selected for study were further goes for the analysis of Urine, creatine, Albumin and other series of test. Results: Lipid profile of the normal group and diabetic group shows the microalbuminuria and macroalbuminuria of diabetic group. The data presented in the table shows the total protein, serum albumin, serum urea, creatinine, GFR and some inflammatory marker which is vitamin-D. It shows the elevated levels of vitamin-D in diabetic patients. Conclusion: It is concluded that vitamin-D binding protein plays an important role and act as serum biomarker for the identification of diabetic nephropathy.

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