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ANALYSIS OF NOVEL BIOMARKERS TO MANAGE OROPHARYNGEAL CARCINOMA AFTER RADIOTHERAPY AMONG LOCAL POPULATION OF PAKISTAN

Naeem Ahmad, Rifat Noor, Muhammad Abubakar

Introduction: Oropharyngeal cancers include cancers of the base of the tongue, tonsil, soft palate, and posterior pharyngeal wall. Many oropharyngeal cancers are difficult to see, even when using a tongue blade and light source. Aim of the study: The basic aim of the study is to find the novel biomarkers which are used to identify the oral cancer before and after treatment of radiotherapy. Methodology of the study: This cross sectional study was conducted in THQ hospital Kamalia during December 2018 to August 2019. Those oral cancer patients who receiving radiotherapy were selected to study the Sialic Acid status in the diseased condition. 5.0 ml saliva sample was taken for the analysis. Saliva was further processed for the estimation of Sialic Acid. Commercially available enzymatic kits of Randox were used. Results: According to our data levels of sialic acid become increases in tongue cancer patients receiving radiotherapy. The levels of sialic acid become highly decreases in oral cancer after radiotherapy. Conclusion: Therfore sialic acid is considerd to be as a dignostic tool in case of tongue cancer patients who recived radiotherapy.

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