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ANALYSIS OF NEURO DEGENERATION IN GLAUCOMA PATIENTS BY TRANSPLANTED DIFFERENT CELL PRECURSORS

Muhammad Adnan Sarwar, Khalida Qasim, Muhammad Adil Nawaz

Objectives of the study: Glaucoma is a common neurodegenerative disease for which current therapies are often insufficient. The purpose of our investigation was to determine whether oligodendrocyte precursor cells (OPCs), a type of neural stem cell, can protect retinal ganglion cells (RGCs) from glaucomatous damage in vivo. Methods: This descriptive study was conducted in DHQ South City Hospital Okara during 2018 to 2019. Intraocular pressure was chronically increased by trabecular laser treatment delivered unilaterally to adult rat eyes. OPCs were isolated in vitro and then transplanted intravitreally either before, or concurrent with, injury induction. Results: Transplanted OPCs were found to survive within the eye for at least 12 weeks and to localize close to the RGCs. Moreover, OPCs significantly enhanced the survival of RGCs in the glaucomatous eye, but only when concomitantly activated by inflammation.. Amelioration of RGC death was not attributable to inflammation but relied on an interaction between inflammatory cells and OPCs. Engrafted cells also displayed multipotentiality in vivo.

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