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REVIEW - ON DO CHRONIC USE OF PROTON PUMP INHIBITORS EFFECT YOUR BONE HEALTH?

Karthik.M, Dinesh Kumar.P, Arshad.P, Naga Jyothi.K

Many medications can cause nutritional deficiencies, and proton pump inhibitors (PPIs) are no different, First is magnesium deficiency. Magnesium (Mg (2+)) is that the second most copious element within human cells and also the fourth most plentiful charged particle within the human body. It is of central importance for a broad form of physiological processes, as well as intracellular signal, neural excitability, muscular contraction, bone formation and protein activation. Several reports have linked long-term PPI use with an increased risk of hypomagnesemia, especially over a year. Results of studies suggest that PPIs inhibit active transport of magnesium in the intestine. Severe hypomagnesemia can potentially lead to serious adverse effects including arrhythmias, hypocalcemia, hypokalemia, hypoparathyroidism, muscle spasms, and seizures. Its overall balance is tightly regulated by the combined actions of the internal organ, bones and kidneys. Disturbance of this balance can have serious consequences. In distinction to prescription PPIs, over-the-counter PPIs are marketed at low doses and are solely meant for a fourteen-day course of treatment up to 3 times each year. FDA believes that there's little risk of hypomagnesemia once over-the-counter PPIs are used in step with the directions on the over-the-counter label. Healthcare professionals need to take into consideration getting humor Mg levels before initiation of prescription PPI treatment in patients expected to induce on these medications for long periods of time, as well as patients who take PPIs with medications such as digoxin, diuretics or drugs which will cause hypomagnesemia. Healthcare professionals should consider obtaining magnesium levels periodically in these patients and the Suggested dose supplementation of magnesium is 250 to 400 mg/day for hypomagnesemia. Keywords: -hypomagnesemia,bone fracture,proton pump inhibitors

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