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HOW MUCH IT MATTERS: A PREDECTIVE ROLE OF PLATELETS IN LIVER INJURY

Yar Muhammad Nizamani, Aamir Hussain, Altaf Khan Pathan3, Khadim Hussain, Madiha Shah, Ashique Ali Arain

Platelets or Thrombocytes are cells without a nucleus with various morphological shapes (Oval, round and biconvex discs) containing granules of physiological, pathological and clinical importance. The plug forming cells have diameter ranging from 2-4 µm derived from megakaryocytes from bone marrow. Platelets (Thrombocytes) perform numerous functions for hemostasis maintenance, response to vascular injury, tissue repair etc. The functions of platelet can be assessed by various parameters like MPV (mean platelet volume) that depicts the size variation (8to12fl) megakaryocyte dependent, PWD (platelet distribution width) and platelet large cell ratio etc. Hepatitis C is an issue of prime concern globally, the virus destroys the liver architecture resulting into hepatic failure and carcinoma. It is a hidden disease and often diagnosed accidently or at a stage of no return with maximum damage occurred. We tried to search into the predictive role of platelets in hepatocellular injury as it is a routine investigation usually done for various purposes. For this purpose we selected 32 patients diagnosed as Cirrhosis and their platelets finding were compared with 32 non-cirrhotic volunteers of age and sex match from LUMHS, and Isra University. We found significant difference between the two groups on various platelet related parameters. Conclusion: It is concluded that higher MPV, Platelet Distribution Width along with low platelet count have a predictive role in advanced liver fibrosis. Key Words: Platelets, Megakaryocytes, MPV, Hepatitis.

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