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TITLE:

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF SPROUTS OF VIGNA RADIATA IN RATS

AUTHORS:

Sri Lakshmi Bajaru* Chandra Sekhar Kommavari, Prasad Konduri, Kumar V. S Nemmani

ABSTRACT:

This study was carried out in order to know that the Methanolic Extract of Vigna radiata (MEVR) possess antidepressant activity or not. This study was done in acute models such as Forced Swim Test (FST), Tail Suspension Test (TST), Reserpine Induced Hypothermia (RIH) and Locomotor activity. Albino wistar rats of either sex weighing around 150-200 g were considered for the study. Imipramine (20 mg/kg, p.o.) was given for standard group, MEVR (400 mg/kg, p.o.) was given for test group and 0.9% NS, p.o. for Vehicle Group. Immobility time was calculated in FST and TST methods, rectal temperature and ptosis score were observed in RIH and in locomotor activity effect of MEVR on locomotion was observed by using Open Field Test in which parameters like total distance, time spent in outer zones and time spent in inner zones were observed.Finally MEVR showed antidepressant activity by significantly reducing the immobility time in FST and also in TST it reduced the immobility time when compare to vehicle group, in RIH it significantly reduced rectal temperature and ptosis when compared to vehicle group and in Locomotor activity no alteration in locomotion was observed. Key words: Antidepressant activity, Vigna radiata, Forced Swim Test (FST), Tail Suspension test (TST), Reserpine Induced Hypothermia (RIH)

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