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GINKGO BILOBA: A SEARCH INTO THE LIPID LOWERING POTENTIAL OF AN ANCIANT HERB

Farzana Rahim Memon, Navaid Kazi, Ghullam Muhammad Phull, Ashfaque Rahim Memon, ArslanUqauli, Salahuddin Shaikh

Cardiovascular system (CVS) is affected by numerous pathologies, dyslipidemia being the common most cause behind IHD a major health concern of the public around the globe with mortality. Many drugs are available in market including Omega-3 fatty acids (poly-unsaturated fatty acids) (PUFAs) essential for human body. Currently, the Omega-3 fatty acids and Ginkgo biloba, have received much attention for medical research for the clinical medicine, in lipid lowering effects, in prevention of cardiovascular diseases. We conducted this study to evaluate the effect of Omega-3 fatty acids, Ginkgo biloba (GkB) and the effect of combined therapy of Omega-3 fatty acids (Ω 3- FAs) and Ginkgo biloba (GkB) on blood lipid profile, in Atherogenic diet fed experimental rats. There were 50 healthy Male Albino Wistar rats were obtained from market and were divided into 5 groups, 10 rats in each group. Groups A, B, C, D, and E. Group A: was control. Group B: High cholesterol diet400mg/kg. Group C: Omega -3- FAs 571mg/kg orally + High cholesterol diet 400mg/kg. Group D: G. Biloba 50mg/kg +High cholesterol diet. Group E:combined mixed therapy of Omega-3-FAs (571mg/kg orally) +G.B (50mg/kg orally) + High cholesterol diet(400mg/kg). Blood samples for TC, TGs, LDL-C, HDL-C were collected from all 5 groups after 4 wks of intervention. There is decrease in TC, TGs, LDL-C levels in experimental group (C, D and E) in comparison to rise in TC, TGs, LDL-Clevels in group B (only High cholesterol fed group); whereas significant increase in HDL-C level is found in experimental group as compared to control group. Combination therapy of omega-3 Fatty acid and Ginkgo biloba (group E) show further significant effects in improving lipid profile when compared to individual treatment groups. Conclusion: Ginkgo biloba decreases total blood lipids, TC, TGs, LDL-C and increases HDL-C but its Combination with omega-3 Fatty acid is more effective. Keywords: Gingko Biloba, Omega-3 Fatty acids, Blood lipid profile.

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