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ASSOCIATION BETWEEN LEVELS OF URIC ACID IMBALANCE TOLERANCE TO GLUCOSE IN THE PATIENTS SUFFERING FROM METABOLIC SYNDROME

Dr. M. Zaheer Abbas, Dr Rabia Babar, Dr Muhammad Ilyas

Objective: The clustering of the risk factors of cardio-metabolism is Met-S (Metabolic Syndrome). Elevated level of uric acid in serum are very common in the patients suffering from CVDs holding various attributes of the Met-S. The part played uric acid in the pathogenesis of Met-S and there was no understanding for the diabetes type-2 development. In this research work, association between the level of uric acid in serum and criteria of Met-S and the study of the OGTT (Oral Glucose Tolerance Test) outcome carried out. Methodology: This research work conducted on 70 patients present with minimum 3 Met-S identification standard recommended by international definitions. After the collection of the twelve hour fasting samples of blood venous blood of the patients, two hour OGTT performed with seventy five gram oral glucose. The level of glucose between one hundred and forty & one hundred and ninety nine mg/dl at hour second was the as imbalance to tolerance to glucose. Results: The two hours’ value of glucose of 23 patients (29.0%) out of 70 patients was determined to be one hundred & forty mg/dl and over. In the analysis of linear regression, we discovered level of uric acid and circumference of waist, BMI and levels of two hour OGTT were present with relationship. Conclusion: In this research work, patients present with high risk of type-2 diabetes, we discovered that the levels of uric acid were present with relation to some components of the Met-S. The concentration of the uric acid had no impact on basal glycaemia & sensitivity of insulin. Keywords: Met-S, Glucose, Circumference, Diabetes, Concentration, Waist, Uric Acid. Glycaemia, Insulin, Sensitivity.

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