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A COMPARATIVE STUDY OF THE SAFETY AND EFFICACY OF INTRAMUSCULAR MIDAZOLAM VERSUS RECTAL DIAZEPAM ACT AS ANTICONVULSANT IN CHLIDREN

Dr Jawad Shabbir, Dr Hadee Atyub, Dr Saad Junaid

Objective: The aim of the study was to determine the efficacy and safety of midazolam given intramuscular to seize seizures in children as compared to rectal diazepam. Study Design: Hospital based descriptive study. Place and Duration: In the Pediatric Unit II of Jinnah Hospital Lahore for one year duration from March 2018 to February 2019. Methods: Children from 1 month to 18 years old had an acute seizure were included in the analysis. Patients were divided into two groups with intramuscular midazolam or rectal diazepam to terminate seizures. The interval duration of the drug administration was compared to stop the seizure. For determination of statistical analysis long range analysis was used. Side effects of both drugs were evaluated. Results: Of the 66 patients, 33 were included in the analysis. For controlling seizures with intramuscular midazolam 45 seconds was the median time interval; There was a significant statistically variation between 2 time groups (p <0.02). In five patients, seizure duration was more than 5 minutes. The side effects in both groups are not statistically significant. Conclusion: In children, Intramuscular midazolam is effective in stopping seizures. It may be alternative management for acute seizures in subjects with rectal or intravenous problems. Keywords: muscular midazolam, seizure, efficacy, safety.

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