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SQUAMOUS CELL CARCINOMA IN THE NECK AND HEAD REGION WITH LYMPHATIC METASTASIS

Dr Rosheena Khan, Dr Umair Altaf, Dr Khurram Hafeez

Objective: SCC (Squamous Cell Carcinoma) is very frequent malignancy in the regions of head and neck with lymphatic metastasis. This research work aimed to assess the identification of this very metastasis from lymphatic channels in the region of the tumor or from the recent formed lymphatic in that very tumor. Methodology: There were 20 patients in this research work with SCC in the head & neck region. The evaluation of these patients carried out for the lymph angiogenesis with the utilization of the Vascular Endothelial Growth Factor-3 & K-I67 immuno-histochemical identifiers and after that the correlation of the collected information carried out with the clinical pathological standards. Results: Huge amount of peritumoral & intratumoral lymphatic densities were present with strongly related with the adverse differentiation on histology. We found no relationship between the intratumoral lymphatic & peritumoral lymphatic densities and the availability of the metastasis of the lymph node, tumor location, age of the patient and gender. We found a strong relationship between both these densities according to Fisher-exact test. Conclusions: This research work shows the availability of the intratumoral & peritumoral lymphatic densities, but there was no association of lymphatic with the metastasis of the lymph node of the SCC in the region of neck & head. Keywords: Lymph Angiogenesis, Immuno-Histochemical, Metastasis, Peritumoral, Fisher, Malignancy, Squamous Cell Carcinoma.

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