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THE RELATIONSHIP BETWEEN CLINICAL AND COLONOSCOPIC FEATURES IN PATIENTS WITH ACTIVE ULCERATIVE COLITIS

Dr.Mehboob yameen, Dr. Ali Nasir, Dr. Muhammad Hassan

Objective: The objective of this study was to advance a classification to mark disease activity based on clinical manifestations in patients with active ulcerative colitis. Another objective was to assess the association of this score with endoscopic disease rigorousness as measured by colonoscopy. Methods: In a pilot study of 43 patients, nine clinical variables were examined by uni-variate analysis.The study was carried in Surgical Department of Allied Hospital Faislabad There were 6 causes which correlated with disease severity, patient’s age, well-being, defecation frequency, stool, extra intestinal manifestations (Ext) and hemoglobin (Hb). Analysis concluded the generation of a new activity index to predict the severity of the disease. This index was performed on 88 patients and validated the definite diagnosis of ulcerative colitis based on previous histological examination. Results: The activity index is derived as follows: (18×bloody stool) + (20×defecation frequency) + (5×Ext) + (15×Hb)- (well-being×17) + (age×2) + 158. Values less than 280 were considered mild, amid 280-310 were considered moderate, and higher than 310 indicated severe disease. This model proved to be correct in almost 71% of the patient’s included in the study. Conclusion: The index results of our study are found to be helpful in considering this technique as useful in evaluating the disease severity levels non-invasively.

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