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ANALYSIS OF EPIDEMIOLOGY OF ORAL HEALTH ISSUES AND IMPORTANT BIOMARKERS FOR THE ANALYSIS OF ORAL CANCER IN PAKISTAN

Hafiza Ambreen Mushtaq, Muizza Arshad, Saira Tasawar

Introduction: Cancers of the oral cavity and pharynx account for 3% of all cancers in the United States. Oral cancer usually includes cancer of the lip, tongue, salivary glands, and other sites in the mouth; while pharyngeal cancer includes cancers of the nasopharynx, oropharynx, and hypopharynx. Objectives of the study: The main objective of the study is to find the important biomarkers which are used for the identification of oral cancer in local population of Pakistan. Methodology of the study: This cross sectional study was conducted in Jinnah Hospital, Lahore during 2018 to 2019. 5.0 ml blood sample was taken from vein. Blood was further processed for the estimation of serum biomarkers i.e glutathione and MDA. Commercially available enzymatic kits of Randox were used. Results: According to our data GSHand MDA shows the maximum decrease in case of tongue cancer patients. There is a maximum change observed in case of tongue cancer patient after radiotherapy. Conclusion: It is concluded that oral health cancer is one of the most leading cause of death in Pakistan and there are number of factors which are associated with this. But GSH and MDA are the two most important bio markers for the identification of oral cancer before and after treatment of radiotherapy in patients.

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