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A REVIEW ON THIAZOLIDINEDIONES AS ANTIDIABETIC AGENTS

Nishad V.M*, Dr .Prasobh G.R., Dr .Sandhya S.M, Anu S, Visal C.S

The thiazolidinediones are the class of oral agents for treatment of type-2 diabetes, improving insulin sensitivity and lowering blood glucose, free fatty acid, and triglyceride levels. The two currently available members of the thiazolidinedione family, rosiglitazone and pioglitazone, have entered clinical practice since 1999. Many clinical agents Troglitazone, Pioglitazone and Rosiglitazone was play an of type- 2 diabetes, however weight gain, hepatotoxicity, urinary blader cancer and cardiovascular toxicity in some population of patient was observed due to this they were banned. Key words: Thiazolidinediones , SAR , type- 2 diabetes.

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