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TITLE:

PHARMACOPHORE AND QSAR STUDY: A REVIEW

AUTHORS:

Reena S R*, Dr .Prasobh G.R., Dr .Sandhya S.M, Sheeja Rekha A G , Athira S

ABSTRACT:

A pharmacophore is an abstract description of molecular features which are necessary for molecular recognition of a ligand by a biological macromolecule. The IUPAC defines a pharmacophore to be "an ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target and to trigger (or block) its biological response".A pharmacophore model explains how structurally diverse ligands can bind to a common receptor site. Furthermore pharmacophore models can be used to identify through denovo design or virtual screening novel ligands that will bind to the same receptor. The process for developing a pharmacophore model generally involves many steps.Pharmacophore modeling is a successful yet very diverse subfield of computer-aided drug design. The concept of the pharmacophore has been widely applied to the rational design of novel drugs. Quantitative structure–activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering. Keywords: Computer-aided drug design, Pharmacophore fingerprint, Protein design, Virtual screening, QSAR

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