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DETERMINATION OF TOTAL ANTIOXIDANT STATUS AND ITS ASSOCIATION TO THE BLOOD LEAD

Farial Javed, Maheen Fatima, Adnan Faiz

Objective: The aim of this research work is to determine the TAS (Total Anti-Oxidant Status) and its association with the blood lead in normal healthy young population of Dera Ghazi Khan, Pakistan. Methodology: This is a transverse research work in which the selection of one hundred young people (55 with levels of blood lead less than seven μg/dl and 45 with levels of blood lead greater than eleven μg/dl) carried out from eight hundred and seventy-two adults having eighteen to sixty year of age choose from population of low salary from Dera Ghazi Khan. Kit of spectrophotometric assay was in use for the analysis of level of TAS in the serum whereas the determination of the levels of blood lead performed with the utilization of the Atomic-Absorption Spectrometric procedure. Results: The average levels of TAS in the serum were low in the persons with high concentration of the lead in the blood in comparison with those having less concentration of the lead in the blood (1.048 ± 0.168 mmol/l versus 1.158 ± 0.138 mmol/l). In a relationship analysis attuned for sex & age, the levels of TAS were available to have link with lead of blood. Conclusion: There were low levels of TAS in the normal healthy population with high concentration of lead in blood. The exposure to the lead pollution could be conceding with the anti-oxidant ability of the persons in this selected population. Keywords: Lead, Cardiovascular Disease, Anti-Oxidant Epidemic, Disrupt, Spectrometric.

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