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STUDY TO ANALYZE THE USE OF NON-INVASIVE PARAMETERS TO DETERMINE VARIOUS STAGES OF LIVER FIBROSIS IN CHRONIC HEPATITIS C VIRUS (HCV) PATIENTS

Dr Zubia Farooq, Dr Rubab Ameer, Dr Maryem Tanweer

Objectives: We aimed in this analysis to determine the different phases of liver fibrosis in chronic hepatitis C virus (HCV) patients by using non-invasive tool like Fibro-scan and bio-chemical parameters. Study Design: This is a case control comparative type of study. Place and duration: This analysis was conducted in Benazir Bhutto hospital Rawalpindi for the duration of one year from March 2018 to February 2019. Methodology: Number of 759 patients were diagnosed by biochemical tests out of which 609 patients were chronic HCV and 150 were normal healthy controls. Number of 609 HCV cases were classified in 05 groups due to liver stiffness according to Fibro-Scan observations which enrolled patients with no fibrosis, mild fibrosis, moderate fibrosis, severe fibrosis and cirrhosis. Just such patients which expressed the existence of HCV RNA (PCR assay) in serum were enrolled in this analysis. HCV cases those were suffering from more than one infection with HIV and Hepatitis B virus were not involved in this analysis. Results: Progressive stage disease cases with severe liver fibrosis and cirrhosis presented raised intensity of aspartate aminotransferase (AST), AST/ALT, gamma-glutamyl transferase (GGT), aminotransferase (ALT), total albumin, lower intensity of albumin, alkaline phosphate (ALP) and haptoglobins matched with controls and were observed significant on the basis of features where the value of P was less than 0.01. group of patients with cirrhosis present raised intensity of ALP, GGT, AST/ALT, AST, ALT and total bilirubin when matched with group of patients without liver complexities and were significant on the basis of facts where the value of P was less than 0.01. haptoglobin and albumin were substantially minimum where the value of P was less than 0.05 in cirrhotic cases versus those with no liver complexities Conclusion: It is concluded through our analysis that mixture of usually accessible biochemical parameters and fibro-Scan are helpful to verify the liver fibrosis and cirrhosis in HCV patients. Key Words: Fibrosis, Alkaline Phosphatase (ALP), Liver Cirrhosis, Aspartate Aminotransferase (AST), Hepatitis C virus (HCV), gamma- Glutamyl-transferase (GGT), Fibro-Scan, Biochemical Markers, Alanine Transaminase (ALT), Haptoglobins.

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