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TOXICOLOGY: A PILOT STUDY ON IMPACT OF LONG TERM USE OF HIGH DOSE PPIs ON RENAL HISTOLOGY AND RENAL FUNCTION TESTS ON RABBIT MODEL

Ashique Ali Arain, Nasreen Qazi, Shahla Imran, Shoukat Ali Memon, Aftab Abbasi, Rizwan Ahmed Memon

A very well-known group of drugs for reducing the acid peptic disease is PPIs (Proton Pump Inhibitors). The adverse effect profile of these agents is a topic of research and discussions in various countries that led to careful usage recommendations from the FDA. We tried to explore the renal toxic effects of these agents at higher doses in rabbit model in a pilot study using very small sample. We found some disturbance in normal renal histology, like inflammatory infiltrations, vacuolization, micro calcifications and some hyaline changes were also observed. Renal functions were also deranged with normal creatinine levels at 0.5 mg/dl and 0.8mg/dl near to control group 0.6 mg/dl but raised serum urea was found as 57mg/dl and 67mg/dl for Esomeprazole and Pantoprazole respectively much higher than the 36mg/dl of the control group similarly Serum electrolytes were also much deranged by both drugs. Conclusion: Disturbance in normal renal histology occurred along with renal functions and serum electrolyte abnormalities following long term use of higher doses of PPIs in study animals. Key Words: Urea, Creatinine, PPIs, histology.

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