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TITLE:

ANALYSIS OF EFFECT OF LEVOCARNITINE ON MUSCLE GLYCOGEN CONTENT IN TYPE 2 DIABETES IN PAKISTAN

AUTHORS:

Muhammad Burhan ulhaq, Ghulam Mujtaba, Sadam Hussain

ABSTRACT:

Introduction: Type 2 diabetes mellitus (T2DM) is a long term metabolic disorder that leads to various complications resulting in decreasing life expectancy by about 10 years. This condition is associated with a derangement in metabolic flexibility, i.e., a derangement in transition from fatty acid to glucose oxidation in response to insulin.Objectives: In this study, we have observed the effects of levocarntine in T2DM by estimating the glycogen stores of skeletal muscle. Methods: This descriptive study was conducted in Bahawalpur Victoria hospital during January 2019 to July 2019. The study involved 30 healthy male Spragu. Serum creatine phosphokinase (CPK) levels were measured to exclude any skeletal muscle disorder. Rats were fed high fat diet (2 weeks) followed by intra-peritoneal injection of streptozocin (35 mg/kg). On 21st day, after confirmation of type 2 diabetes by measuring plasma glucose and TG/HDL ratio, rats were divided into 2 equal groups; group I (Diabetic) and group II (Carnitine). Group II was administered l-carnitine (200mg/kg) for 6 days. The extensor digitorum muscle (EDL) of rats of both groups were dissected for estimation of muscle glycogen content. The serum free carnitine (FC) levels were also measured. Results: Carnitine treated rats resulted in increase in skeletal muscle glycogen stores (p<0.001). Serum free carnitine levels were also found to be higher in carnitine groups. Conclusion: Levocarnitine increases the glycogen stores in type 2 diabetic rats.

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