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Mrs.Sheeja Rekha A. G *, Dr. Prasobh G. R, Mr.Nishad V.M, Mrs. Athira A.S, Mr.Visal C.S
Sulfonamide drugs were the first antimicrobial drugs. The first sulfonamide was trade named Prontosil, which is a prodrug Prontosil, the first commercially available antibacterial with a relatively broad effect The sulphonamides or sulfa drugs competitively inhibit folic acid synthesis in micro-organisms and subsequently inhibit multiplication of bacteria but do not actively kill them. They have been used against most gram-positive and many gram-negative bacteria, some fungi, and certain protozoa. Keywords-SAR of sulfonamides