::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ABDOMINAL COMPUTED TOMOGRAPHY FINDINGS AND HEPATIC DYSFUNCTION ASSOCIATED WITH SCRUB TYPHUS

AUTHORS:

Shahzad Saleem, Muhammad Habib Ur Rahman, Muhammad Asad Awan

ABSTRACT:

Objective: This retrograde research work interrogated the hepatic dysfunctions and abnormal findings of CT (Computed Tomography) in the patients diagnosed with scrub typhus. Methodology: 349 patients were present with confirm scrub typhus. 94 patients underwent computed tomography of abdomen cavity. The review of the computed tomography images was carried out by the radiologist. We collected the data of the patients about the history of disease, signs, clinical symptoms and findings of laboratory testing from the electronic clinical records of these patients. Results: In 349 patients present with scrub typhus, aspartateamino-transferase’s elevation (78.50%) & alanineamino-transferase (63%) were much dominant in comparison with the alkaline phosphatase (27.20%) &total bilirubin (16.10%). Abdominal computed tomography findings of ninety four patients were, in decreasing order of rate of occurrence, enlarged lymph-node (53.20%), inhomogeneous liver’s enhancement (47.90%), splenomegaly (46.80%), ascites (28.70%), less attenuation in the periportal regions (27.70%), thickening of the wall of gall bladder (17%) and infarct of spleen (6.40%).Also, there was tendency of elevation in the level of the aspartate amino-transferase in accordance with the findings of computed tomography (P= 0.0280). Conclusions: The findings of this research work concluded that abdominal manifestation of CT of scrub typhus with raised amino-transferases was present with variation and they were not specific. However, awareness of these outcomes may evoke the scrub typhus’s recognition by the health professionals in endemic regions. KEYWORDS: Tomography, Gall Bladder, Alanine, Splenomegaly, Aspartate, Abdomen, Phosphatase, Dysfunction, Scrub Typhus.