::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CORRELATION OF HIGH-SENSITIVITY C-REACTIVE PROTEIN AND CAROTID COLOR ULTRASONOGRAPHY IN DIAGNOSIS OF ATHEROSCLEROTIC CEREBRAL INFARCTION

AUTHORS:

Dr Shahryar Aamir, Dr Usama Bilal Ahmad, Dr Ozair Bilal Ahmed

ABSTRACT:

Objectives: The aim of this research work was to identify the association between high-sensitive C-reactive protein, function of neurological function, carotid plaque and thickness of intima-media, and to support the professionals in the identification of ACI (Atherosclerotic Cerebral Infarction). Methodology: A sum of 96 patients with the 1st onset of Atherosclerotic Cerebral Infarction were the participants of this research work from May 2017 to June 2020. We carried out the test for high-sensitive C-reactive protein, evaluation of the neurological function and investigation with the help of carotid color US (Ultrasonography) for all the patients of this research work. Results: We divided 96 patients in to groups; plaque group (PG) and non-plaque group (NPG) keeping in view the presence of the carotid plaque after application of carotid artery US. We further subdivided the PG into unstable plaque & stable plaque sub-groups keeping in view the characteristics of the plaque. The age of the patients of both sub-groups was much high as compared to the patients of NPG (P<0.050). Unstable plaque sub-group appeared with high value of intima-media thickness and level of high-sensitive C-reactive protein, followed by the sub-group of stable plaque and NPG (P<0.050). There was increase in the level of high-sensitive C-reactive protein with the increase in the value of nervous damage scale (P<0.050). Additionally, there was a significant association between the scores of NIHSS and high-sensitive C-reactive protein in the patients suffering from Atherosclerotic Cerebral Infarction (P<0.050). Conclusion: There is close association of the high-sensitive C-reactive protein & intima-media thickness with development of carotid plaque, and high-sensitive C-reactive protein can be considered as highly sensitive index in the identification of the prognosis and risk for Atherosclerotic Cerebral Infarction. KEY WORDS: High-sensitive, C-reactive protein, Intima-media thickness, prognosis, NPG, PG, carotid plaque, methodology.