Shaik Sultan Basha, Qudrath Ullah Khan, Mohammed Abdul Mannan, Abdul Waheed and Syeda Rana Nikhat*
OBJECTIVS: To identify common complications in type-2 DM, also commonly prescribed medications to treat them along with type-2 DM and to identify adverse drug reaction and drug-drug interactions during the course of treatment at tertiary care teaching hospital. MATERIALS AND METHODS: A total of 100 patients with presumed and/or confirmed T2DM along with DM complications were observed. The data recorded related to the disease parameters and the pattern of treatment regimen were further evaluated as per ADA guidelines. The MMAS-4 was used to determine patient’s adherence to medications, Hartwig’s Severity Assessment Scale to determine severity of adverse reaction and Micromedex® drug interactions and drug information android app was used to determine drug-drug interactions and adverse reactions. RESULTS: A total of 100 prescriptions of the T2DM patients receiving antidiabetic agents were evaluated, among which 71% were male and 29% were female, with 42% of diabetic history of less than 5 years and 74% shown high adherence to the prescription. Most were found to exhibit more than one complication and among macrovascular complications, hypertension (73 cases) is more prevalent and among microvascular complication, nephropathy (32 cases) was found to be more common. Majority of the potential DDIs were of moderate severity, ADRs were of moderate severity and the interactions were pharmacokinetic in nature in our study. CONCLUSION: In this study, Diabetes Mellitus associated complications were identified and management of complications were evaluated. This study shows the drug utilization pattern of complications among type-2 diabetic patients. The present study suggests that the clinical pharmacist involvement in disease management can have positive impact in creating awareness about the disease. Keywords: Type 2 Diabetes Mellitus, Anti-diabetic Agents and Diabetic Complications.