::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

PATTERNS OF ANTIMICROBIAL RESISTANCE AMONG PATIENTS IN THE INTENSIVE CARE UNIT

AUTHORS:

Dr Zainab Tariq, Dr Mubashar Shaukat, Dr Shaista Khalid

ABSTRACT:

Given the importance of nosocomial infections (HAI), it is essential to conduct follow-up studies to obtain the required data on local microorganisms and their susceptibility to antibiotics. This study investigated the pattern of antimicrobial resistance among patients in intensive care unit (ICU). Study Design: A cross-sectional study. Place and Duration: In the Medicine Unit-II of Jinnah Hospital Lahore for one-year duration from April 2019 to April 2020. Methods: 100 samples were collected from patients admitted to the ICU with symptoms or symptoms of nosocomial infection. Blood, urine, tracheal aspirate, sputum, wound swab, pus, and tracheal tubes were sampled from each patient, cultured, and analyzed by antibiogram. Results: The most common primary diagnosis was aspiration pneumonia (49%) and UTI (20%), respectively. The most common sites of infection were tracheal aspirates (54%). The most common sample-derived Gram-negative microorganisms were Acinetobacter spp (29%), Klebsiella spp (26%) and Pseudomonas spp (18%). Klebsiella spp., Acinetobacter spp. And Pseudomonas spp. They were the most common resistant organisms of all. Klebsiella spp were resistant to ceftriaxone (84.6%), ceftazidime (82.6%), amikacin (46.1%), gentamicin (66.6%) and quinolones (65-66.6%), respectively. Acinetobacter spp were resistant to ceftriaxone (85%), ceftazidime (88.8%), cefotaxime (85.7%), meropenem (79.3%), amikacin (86.2%), gentamicin (84.5%) and quinolones (86.2-89.2%). Pseudomonas spp were resistant to ceftriaxone (70.5%), ceftazidime (66.6%), amikacin (68.7%), gentamicin (58.8%), meropenem (52.9%) and quinolones (81 2-86.6%). Meropenem was the most sensitive antibiotic to Klebsiella spp (84.6%), and co-trimoxazole in Acinetobacter spp (60%), respectively. Escherichia coli were mostly isolated from urine, which was sensitive to amikacin (73.3%) and meropenem (86.6%), respectively. Conclusion: Gram-negative pathogens obtained from ICU patients in our facilities show high resistance to antibiotics. Regular monitoring of resistance patterns of common pathogens in intensive care units is essential for the current application of sound antibiotic ceilings. Key words: antibiotic, microbes, nosocomial infections, healthcare associated infections, antimicrobial resistance.