::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

News Updates Latest Volumes: COSMOS IMPACT FACTOR (2018)- 4.153, GLOBAL IMPACT FACTOR(2014) - 0.384, (2015) - 0.437, Indo American Journal of Pharmaceutical Sciences,

ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

TITLE:

HIGH PERVASIVENESS OF MULTIPLE DRUG RESISTANCE AMONGST ESCHERICHIA COLI INFECTIONS IN PEDIATRIC PATIENTS

AUTHORS:

Dr Zulaikha Yaqoob, Dr Mirza Aun Muhammad Baig, Dr Zarnain Tariq

ABSTRACT:

Antimicrobial resistance is a major health risk. The number of infections caused by numerous drug-resistant microorganisms is increasing, making community-acquired infections a physician's nightmare. Objective: A survey was conducted to assess the prevalence of multiple drug-resistant urinary tract pathogens affecting children. Place and Duration: In the Pediatric Unit of Shalamar Medical and Dental College Lahore for one-year duration from March 2019 to March 2020 Methods: Urine samples were collected from children under five years of age. Urine samples were considered positive cultures when a single bacterial species with a colony count> 105 CFU / ml was grown. A total of 240 urine samples were collected, of which only 67 were positive. It was found that 67% and 18% of the infections were caused by E. coli and Staphylococcal species, respectively. Other bacteria that cause urinary tract infections include Klebsiella, Citrobacter, and Pseudomonas. The antimicrobial susceptibility pattern of E. coli isolates was tested on 10 commonly prescribed antimicrobial drugs for urinary tract infections because E. coli was the predominant uropathogenic factor. Results: About 66 percent of the isolates were resistant to 3 or more drugs. 46 percent of E. coli isolates were resistant to the 5 antibiotics tested. Augmentin (64%) showed the highest resistance. E. coli resistance to Norfloxacin and Cefuroxime was 60%. Approximately 94% of the isolates were sensitive to netilmicin. None of the investigated drugs were effective against all E. coli isolates. Conclusion: This type of questionnaire can serve as a guideline for initiating the empirical treatment of community-acquired urinary tract infections pending the generation of culture reports. Key words: multi-drug resistance, E. coli, urinary tract infection, children, children.