- CODEN : IAJPBB
- issn 2349-7750
TITLE:
AETIOLOGICAL AGENTS FOR PULMONARY EXACERBATIONS IN CHILDREN WITH CYSTIC FIBROSIS: AN OBSERVATIONAL STUDY IN FAUJI FOUNDATION HOSPITAL RAWALPINDI PAKISTAN
AUTHORS:
Dr Fatima Naz Awan, Dr Tania Saif , Dr Maria Tariq
ABSTRACT:
Background- In cystic fibrosis the main cause of mortality and morbidity is pulmonary disease. Normally with particular pattern of bacterial pathogens which depend upon age, this infection occurs. Objective- The goal of this study is to determine the aetiological agents with cystic fibrosis in children for pulmonary exacerbations and find out its relationship with demographic variables. Method- This study is based on observations for these 104 children were selected with cystic fibrosis with pulmonary exacerbations and they all tested by using proper laboratory techniques for viral pathogens, mycobacteria, fungi and bacteria. With demographic variables isolation frequency of different organisms were associated and calculated. Results- Out of all selected children 29% i.e. 27 children were isolated in viral RNA, 35% i.e. 37 were isolated with bacteria. In 29.8% i.e. 31 children the growth of most common Pseudomonas bacteria was found while in 3 i.e. 2.9% isolated for Burkholderia cepacian complex (Bcc) was found. The most common virus among all virus was Rhinovirus and this was found in 17.4% i.e. 16 patients while in 4 i.e. 4.3% coronavirus was identified. Mycobacteria and fungi were isolated from 4 (3.7%) and 23 (22%) children respectively. The most common fungus found was Aspergillus flavus from 12.5% i.e. in 13 children. Conclusion- During exacerbation Pseudomonas was found as most common organism. Infection with Mycobacterium tuberculosis and Bcc was observed whereas infection with tuberculous mycobacteria was not observed. In CF morbidity Mycobacterium tuberculosis and Bcc have a role. However, severe exacerbations had association with polymicrobial. Keywords: Polymicrobial infection, Pseudomonas, microbiology, cystic fibrosis, children, acute exacerbation
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NLM ID:101711216 [Serial]
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