- CODEN : IAJPBB
- issn 2349-7750
TITLE:
ASSOCIATION BETWEEN ISCHEMIC STROKE AND HOMOCYSTEINE
AUTHORS:
Dr. Safa Khalil, Dr. Fatima Amir Cheema, Dr. Abida Bashir
ABSTRACT:
Background: Epidemiological studies have identified hyperhomocysteinemia as a possible risk factor for atherosclerosis. The aim of the study was to assess the relationship between homocysteinaemia and patients with ischemic stroke. Methods and Materials: This was a prospective observational study conducted at the Neurology department and Medicine Unit-II of Services Hospital, Lahore for one-year duration from May 2019 to April 2020. Thirty-six consecutive ischemic stroke patients were analyzed for total homocysteine, total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides, and an equal number of age-matched controls were compared to a group of cases. Result: The mean fasting blood sugar level, fasting total cholesterol (TC) in the serum, and low-density lipoprotein (LDL) in the serum were significantly higher in the group of patients (p = 0.001). Serum TC and LDL levels correlated positively with serum homocysteine (p = 0.001). High-density lipoprotein (HDL) in serum showed a negative correlation (p = 0.718), and serum triglycerides (TG) had a negative correlation (p = 0.182). The total level of fasting homocysteine in the group of patients was 21.89 ± 9.38 μmol / L, and in the control group it was 12.31 ± 3.27 μmol / L (p = 0.001). Elevated levels of fasting homocysteine were found in 75.0% of patients with ischemic stroke and in 16.67% of healthy subjects (p = 0.001). The incidence of hyperhomocysteinemia is higher in ischemic stroke than in age and sex-matched healthy controls. Conclusion: In our study, hyperhomocysteinemia in patients with ischemic stroke was identified as a vascular risk factor. A significant correlation was found between the concentration of homocysteine and ischemic stroke. Key words: homocysteine, carotid stenosis, ischemic stroke
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