::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

MATERNAL SERUM URIC ACID LEVELS AT DELIVERY AMONG GESTATIONAL HYPERTENSIVE WOMEN

AUTHORS:

Dr Abdullah, Dr Shafi Ullah Khan, Dr Aqib Majeed Khan

ABSTRACT:

Introduction: Hypertensive disorders complicating pregnancy are the most common and serious medical disorder and constitute up to 2–10% of all pregnancies. Gestational hypertension (GH), preeclampsia (PE), and eclampsia are a part of a spectrum of hypertensive disorders that complicate pregnancy as specified by the National High Blood Pressure Education Program (NHBPEP) working group. Aims and objectives: The basic aim of the study is to analyze the maternal serum uric acid levels at delivery among gestational hypertensive women and its effect on fetal growth. Material and methods: This cross sectional study was conducted in Nishtar Hospital, Multan during January 2020 to June 2020. The data were collected from 100 pregnant female patients with gestational age above 32 weeks. The selected participants were divided into 2 groups, one with GH and second group with NP. All the participants were age matched. GH is defined as denovo hypertension with systolic blood pressure (SBP) ≥140 mmHg and diastolic blood pressure (DBP) ≥90 mmHg after 20 weeks of gestation. PE is GH with proteinuria – 1+ on dipstick or ≥300 mg/day or Pr:Cr ratio as ≥3.0 mg/g. Results: The data were collected from 100 randomly selected participants. The mean age for NP were 23.2 ± 2.9 and for GH 22.9 ± 3.0. The mean age and gestational age among both groups were not statistically significant. SBP, DBP, and urinary proteins were significantly different in the both groups. Conclusion: It is concluded that Serum uric acid and creatinine are elevated in GH whereas no significant difference was observed between PE and NP. Serum uric acid had better specificity and sensitivity for GH and also correlated negatively with fetal birth weight.