- CODEN : IAJPBB
- issn 2349-7750
TITLE:
A PROSPECTIVE OBSERVATIONAL STUDY ON DRUG-DRUG INTERACTIONS IN CARDIAC PATIENTS AT A TERTIARY CARE HOSPITAL
AUTHORS:
Javed Akhtar Ansari, Farheen Fatima, Syeda Amtul Raqiba, Qanita Munazza, Mohammed Afanullah Khan
ABSTRACT:
Aims and objectives: Drug–drug interactions (DDIs) are defined as two or more drugs interacting in such a manner that the effectiveness or toxicity of one or more drugs is altered. Patients with cardiovascular disorders are at higher risk for drug- drug interactions because of the types and number of drugs they receive. The aim of the present study was to assess the incidence and prevalence of DDIs in cardiac patients Subjects and methods: A prospective observational study was carried out for a period of 6 months at Osmania General Hospital, a Tertiary Care Teaching Hospital. Cardiac patients taking at least two drugs and who had a hospital stay of at least 24 hours were included in the study. The prescription was analyzed for possible interactions using - Micromedex -2 (Thomson Reuters) × 2.0. Results: A total of 150 patients were included in the study in which 719 drug-drug interactions were found. Among these males 72% were predominant. Majority of interactions were of moderate severity (68.98%) and pharmacodynamic (73.99%) in nature. Among the clinical consequences, the incidence of bleeding (55.39%) was found to be highest. CAD’s were found to be the major cause of hospitalizations (43.34%). The class of drugs most commonly involved in drug-drug interactions was found to be Anticoagulants & Antiplatelet (34.18%). Conclusion: This study highlights the need for screening prescriptions of cardiovascular patients for DDIs and proactive monitoring of patients who have identified risk factors; this helps in detection and prevention of possible adverse drug interactions. Keywords: Cardiovascular disorders, Drug–drug interactions, Interaction severity, Micromedex
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NLM ID:101711216 [Serial]
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